Rochester, Minn. Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients with Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma Study type: Interventional What is this? Phase 3 trials include large numbers of people to make sure that the result is valid. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market. Monoclonal antibody-drug conjugates, such as brentuximab vedotin, can block cancer growth in different ways by targeting certain cells. It is not yet known whether brentuximab vedotin and combination chemotherapy is more effective than crizotinib and combination chemotherapy in treating anaplastic large cell lymphoma. Participating Mayo Clinic locations Study statuses change often. Phase 3 trials include large numbers of people to make sure that the result is valid. Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.