People with diabetes should use caution when taking glucosamine because it may raise blood sugar. People who are allergic to shellfish also should consult their doctors before using glucosamine and chondroitin. Glucosamine is extracted from a substance in shellfish. The effects of these supplements on a growing child or developing baby are not yet known. What Are the Side Effects of Glucosamine and Chondroitin? The most commonly reported side effects of glucosamine and chondroitin include: What Is MSM and Can It Help My Arthritis? MSM, or methylsulfonylmethane, is a supplement that is used to try to help a wide range of conditions, including arthritis, allergies, and even snoring. MSM is an odorless and tasteless natural sulfur compound found in all living things.