While lymphomas in adults are more commonly low or intermediate grade, almost all NHL that occurs in children is high grade. Clinical trials in pediatrics are designed to compare potentially better therapy with therapy that is currently accepted as standard. All children with non-Hodgkin lymphoma (NHL) should be considered for entry into a clinical trial. Children with NHL should be referred for treatment by a multidisciplinary team of pediatric oncologists at an institution with experience in treating pediatric cancers. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. The health professional versions have detailed information written in technical languag