Medicines are the main treatment for rheumatoid arthritis. The types of medicines used depend on how severe your disease is, how fast it is progressing, and how it affects your daily life. If your symptoms get worse, you will have to start taking medicine again. Signs of joint inflammation include swelling, tenderness, and limited range of motion. Prevent or delay significant joint damage and deformity. Medicines called disease-modifying antirheumatic drugs (DMARDs) can slow or sometimes prevent joint destruction. Starting treatment early with DMARDs can reduce the severity of the disease.2 DMARDs are also called immunosuppressive drugs or slow-acting antirheumatic drugs (SAARDs). These medicines are usually taken over a long period to help control the disease.